Human recombinant R-spondin 3

Fornecedor: Tonbo Biosciences
21-7128-U100EA 612 EUR
21-7128-U100 21-7128-U500 21-7128-U005 21-7128-U020
Human recombinant R-spondin 3
R-Spondin 3 (RSPO3) is a secreted protein belonging to the R-Spondin family of four structurally related Wnt/beta-catenin signaling regulators. All four members contain one thrombospondin-like and two furin-like domains. Studies indicate that R-Spondin 3, prominently expressed in hematopoietic organs, acts as an angiogenic factor during embryogenesis. R-Spondins can enhance Wnt/beta-catenin signaling as they compete with the Wnt agonist DKK-1 for binding to Wnt co-receptors LRP6/Kremen. They can also act as a signaling activation ligand on LRP6 and LGR4 to form a cluster with WNT and FZD. The R-Spondins have been demonstrated to bind to LGR-4, LGR-5 and LGR-6 receptors with high affinity.

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