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Anti-CD146/MCAM Rabbit Polyclonal Antibody

Fornecedor: BioVision
The CD146 antigen, also known as MCAM, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. CD146 is expressed predominantly on metastatic lesions and advanced primary tumours, and has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

Recommended Dilutions: Western Blot: 1:1000, IHC: 1:10-1:50.

Type: Primary
Antigen: CD146/MCAM
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-terminal
Host: Rabbit
Isotype: IgG
Reactivity: Human.



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ENCOMENDA

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Tamanho Und. Tipo de embalagem. Referência VWR Quantidade
100 μl 100 µl Vial BIOV6801-100
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ESPECIFICAÇÕES

Antigen symbol CD146
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
Antigen synonyms MCAM, S-endo 1 endothelial-associated antigen,
Epitope C-terminal
Cross adsorption No
Immunogen This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of human MCAM.
Purification Protein A column, followed by peptide affinity purification.
Form Liquid
Storage buffer In PBS with 0,09% (W/V) sodium azide.
Temperatura de armazenamento – 20 °C
Shipping temperature 4 °C
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