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Anti-MMP2 Rabbit Polyclonal Antibody

Fornecedor: Thermo Scientific
In Western Blot, bands can be seen at approximately 72kDa (proform) and 62kDa (active form). Antigen retrieval is not required for IHC. Suggested positive control: Injured rat nerve lysate. Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix matalloproteinases. MMP-2, the signalling mechanism for cells to begin migration, triggers the movement when it splits laminin-5 and exposes and integrin-binding site on this component of epithelial basement membrane. The changed form of laminin was found in tumors and in tissues being altered. The activated form of MMP2, however, is not found in benign tumors. Thus detection of the enzyme is a possible early indicator of tumor activity.

Type: Primary
Antigen: MMP2
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Mouse, Human, Chicken

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Tamanho Und. Referência VWR Quantidade
100 µL 100 µl PIEAPA116667 Blocked
Blocked Este produto está bloqueado. Para obter mais informações, contacte a VWR através do número 213 600 770.
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Antigen symbol MMP2
Antigen name Matrix Metalloproteinase 2
Reactivity Rat, Chicken, Human, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Flow cytometry Yes
Antigen synonyms CLG4A, Gelatinase neutrophil, CLG 4A, 72 kDa gelatinase, 72kD type IV collagenase, Mat, Gelatinase alpha, Collagenase Type 4 alpha, Gelatinase A, CLG4
Gene ID 4313, 386583, 17390, 81686
Concentração 1 mg/ml
Immunogen A synthetic peptide corresponding to residues 475-490 of human MMP-2: MGPLLVATFWPELPEK
Purification Antigen affinity chromatography
Form Liquid
Storage buffer PBS, 0.05% sodium azide
Temperatura de armazenamento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping temperature Ice

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